Application Support Engineer (Third Party Systems), London

Isomorphic Labs is applying frontier AI to help unlock deeper scientific insights, faster breakthroughs, and life-changing medicines with an ambition to solve all disease.

The future is coming. A future enabled and enriched by the incredible power of machine learning. A future in which diseases are curtailed or cured starting with better and faster drug discovery.

Come and be part of an interdisciplinary team driving groundbreaking innovation and play a meaningful role in contributing towards us achieving our ambitious goals, while being a part of an inspiring and collaborative culture.

The world we want tomorrow is the one we’re building today. It starts with the culture at this company. It starts with you.

About Iso

Isomorphic Labs (IsoLabs) was launched in 2021 to advance human health by building on and beyond the Nobel-winning AlphaFold system. Since then, our interdisciplinary team of drug discovery experts and machine learning specialists has built powerful new predictive and generative AI models that accelerate scientific discovery at digital speed.

Our name comes from the belief that there is an underlying symmetry between biology and information science. By harnessing AI’s powerful capabilities, we can use it to model complex biological phenomena to help design novel molecules, anticipate how drugs will perform and develop innovative medicines to treat and cure some of the world’s most devastating diseases.

We have built a world-leading drug design engine comprising AI models that are capable of working across multiple therapeutic areas and drug modalities. We are continually innovating on model architecture and developing cutting-edge capabilities to advance rational drug design.

Every day, and with each new breakthrough, we’re getting closer to the promise of digital biology, and achieving our ambitious mission to one day solve all disease with the help of AI.

Your impact

We are seeking a talented Integration Engineer to own, secure, and scale our suite of internal, multi-user tools and applications.

You will be responsible for a number of vendor applications that we deploy in our own environments. You will bridge the gap between Integration, Operations, and Security. You will be responsible for the full software lifecycle; from configuring secure cloud environments, orchestrating application deployments, running automated security scanning, and executing continuous updates with minimal downtime.

What you will do

• Platform Deployment & Lifecycle Management:
• Deploy, upgrade, patch, and maintain multi-user self-hosted software instances across cloud environments.
• Plan and execute seamless, low-downtime application maintenance and database migration windows.
• Integrate with customer identity platforms to provide secure access.
• Configure monitoring and alerting, with runbooks for application health management
• Continuous Deployment & Orchestration:
• Build and maintain continuous deployment pipelines to automate application delivery (primarily for Kubernetes).
• Maintain Infrastructure-as-Code (IaC) templates and configuration management scripts for reliable instance provisioning.
• Application Security & Vulnerability Scanning:
• Integrate continuous security scanning into pipelines to inspect application code, dependencies, and container images for vulnerabilities.
• Remediate identified CVEs and enforce compliance and security standards across all internal platform tooling.
• Identity & Access Integration: Configure Single Sign-On (SSO), Role-Based Access Control (RBAC), and directory integration (SAML 2.0 / OIDC) for onboarded applications.
• Endpoint & Cloud Deployment: Automate and manage software rollouts across desktop fleets, headless Linux machines, and cloud environments using modern deployment pipelines and configuration tools.
• Configuration & Hardening: Enforce security baseline configurations, secrets management, and access controls for all newly introduced software packages.

Skills and qualifications

Essential

• Hands-on Kubernetes & Containerization: Experience deploying, managing, and scaling multi-user applications on Kubernetes
• CI/CD & Automation: Proven track record building continuous deployment pipelines using tools such as GitHub Actions, GitLab CI, ArgoCD, or Jenkins.
• Security Scanning & Vulnerability Management: Experience implementing and analyzing container and dependency security scanning tools
• Infrastructure as Code (IaC): Proficiency with Terraform, OpenTofu, or similar for provisioning repeatable environments.
• Identity & Access Management (SSO): Practical experience configuring Single Sign-On (SSO) and Directory integration via SAML 2.0 / OIDC (e.g., Okta, Azure AD/Entra ID).
• Scripting Skills: Proficiency in Python, Bash, or Go to automate maintenance routines and internal workflow.

Nice to have

• GitOps Methodology: Hands-on experience with GitOps tools like ArgoCD or Flux for declarative state enforcement.
• Database & Storage Administration: Experience backing up, restoring, and tuning databases commonly used by self-hosted applications (PostgreSQL, MySQL, Redis).
• Observability Stacks: Experience using monitoring, alerting, and logging tools

Culture and values

We are guided by our shared values. It's not about finding people who think and act in the same way. These values help to guide our work and will continue to strengthen it.

Thoughtful

Thoughtful at Iso is about curiosity, creativity and care. It is about good people doing good, rigorous and future-making science every single day.

Brave

Brave at Iso is about fearlessness, but it’s also about initiative and integrity. The scale of the challenge demands nothing less.

Determined

Determined at Iso is the way we pursue our goal. It’s a confidence in our hypothesis, as well as the urgency and agility needed to deliver on it. Because disease won’t wait, so neither should we.

Together

Together at Iso is about connection, collaboration across fields and catalytic relationships. It’s knowing that transformation is a group project, and remembering that what we’re doing will have a real impact on real people everywhere.

Creating an extraordinary company

We believe that to be successful we need a team with a range of skills and talents. We're building an environment where collaboration is fundamental, learning is shared and every employee feels supported and able to thrive. We value unique experiences, knowledge, backgrounds, and perspectives, and harness these qualities to create extraordinary impact.

We are committed to equal employment opportunities regardless of sex, race, religion or belief, ethnic or national origin, disability, age, citizenship, marital, domestic or civil partnership status, sexual orientation, gender identity, pregnancy or related condition (including breastfeeding) or any other basis protected by applicable law. If you have a disability or additional need that requires accommodation, please do not hesitate to let us know.

Hybrid working

It’s hugely important for us to share knowledge and build strong relationships with each other, and we find it easier to do this if we spend time together in person. This is why we follow a hybrid model, and would require you to be able to come into the office 3 days a week (currently Tuesday, Wednesday, and one other day depending on which team you’re in). If you have additional needs that would prevent you from following this hybrid approach, we’d be happy to talk through these if you’re selected for an initial screening call.

Please note that when you submit an application, your data will be processed in line with our privacy policy .

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