Senior ML Research Engineer, Virtual Cell
SandboxaqLocation: CanadaOpen for: 12+ days
- Workplace: Remote
- $126k to $222k a year CAD
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About SandboxAQ
SandboxAQ is a high-growth company delivering AI solutions that address some of the world's greatest challenges. The company’s Large Quantitative Models (LQMs) power advances in life sciences, financial services, navigation, cybersecurity, and other sectors.
We are a global team that is tech-focused and includes experts in AI, chemistry, cybersecurity, physics, mathematics, medicine, engineering, and other specialties. The company emerged from Alphabet Inc. as an independent, growth capital-backed company in 2022, funded by leading investors and supported by a braintrust of industry leaders.
At SandboxAQ, we’ve cultivated an environment that encourages creativity, collaboration, and impact. By investing deeply in our people, we’re building a thriving, global workforce poised to tackle the world's epic challenges. Join us to advance your career in pursuit of an inspiring mission, in a community of like-minded people who value entrepreneurialism, ownership, and transformative impact.
The Opportunity
The AI Sim R&D team builds leading-edge ML and physics-based models ("LQMs") to advance drug discovery. Within this team, AQCell is our virtual cell platform: it takes a cell representation (e.g. basal gene expression) and a perturbation descriptor (e.g. SMILES, dose, and time), predicts the resulting transcriptomic response, and maps that response through pathway activity to functional endpoints such as cell viability, IC50, and toxicity dose-response — helping drug discovery scientists understand the biological repercussions of a compound across the cell, not just whether it binds its target.
As a Machine Learning Engineer on AQCell, you will build and maintain the models and data infrastructure that power this pipeline. You will work across large, heterogeneous transcriptomic and functional-endpoint datasets (e.g. LINCS L1000, GDSC, Tahoe-100M, and DILImap), train and evaluate expression-perturbation and cell-viability prediction models over them, and help harden our evaluation pipeline and baselines so we can trust and improve model performance over time. This role sits at the intersection of machine learning and biology, and offers the opportunity to shape how virtual cell models are trained, validated, and scaled toward real drug discovery decisions.
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Last checked Nov 2, 2026.
Why Join Us?
We offer competitive compensation, a comprehensive benefits package, and opportunities for professional growth.
SandboxAQ Welcomes All
We are committed to fostering a culture of belonging and respect, where diverse perspectives are actively sought and valued. Our multidisciplinary environment provides ample opportunity for continuous growth - working alongside humble, empowered, and ambitious colleagues ready to tackle epic challenges.
Equal Employment Opportunity : All qualified applicants will receive consideration regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity, or Veteran status.
Accommodations : We provide reasonable accommodations for individuals with disabilities in job application procedures for open roles. If you need such an accommodation, please let a member of our Recruiting team know.
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